Animal experimentation that recapitulates severe human trauma has been generally unsuccessful due to our inability to utilize a model that allows long term follow-up of severely injured animals, with many studies focusing on early time points less than 24 hours ( 2, 9, 10). This is partially due to a lack of adequate translational research with limited animal models. ![]() However, the exact mechanisms behind these phenomena in trauma patients remain unknown, and MOF remains a major source of post-injury morbidity and in-hospital mortality ( 6, 8).Ĭurrently, our understanding of and capacity to improve the poor outcomes in human trauma patients due to immunological dysregulation has been limited. There has been a substantial body of research on the immunologic origin of the infectious complications leading to prolonged ICU stays, sepsis, and multiple organ failure (MOF) ( 7). There appear to be many common immune responses following both trauma and sepsis, and it is thought that immunological dysregulation following trauma contributes to poor outcomes ( 4– 6). ![]() Despite advances in trauma care via the advent of aggressive early management and improved intensive care unit (ICU) support, morbidity and mortality, especially from complications remain prohibitively high ( 3). ![]() Trauma with massive injury is the most common cause of death in patients under the age of 45, and the hemorrhagic shock that frequently accompanies trauma increases mortality as well as infectious complications ( 1– 3).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |